Photo-Responsive Carrier for Hydrophobic Small Molecule Delivery at Target Site

The University of Hong Kong Background

Retinoblastoma is a severe eye cancer of infancy and childhood and can cause blindness or even death.
Currently, the invasive intravitreal drug administration used in clinics is unpleasant for patients and can lead to side effects such as ocular haemorrhage, endophthalmitis and retinal detachment, etc.
Thus, effective drug administration routes in a less invasive manner are desirable for the treatment of retinoblastoma.

Technology Overview
Underlying Mechanism

Three-legged small molecules are the main building blocks of the nanocarriers.
The cleavage of the three-legged molecules upon light irradiation can quickly lead to the breakdown of the nanocarriers, resulting in the rapid release of the drugs only at the irradiated sites.

Benefits

On-demand drug delivery to achieve a less invasive and more efficient treatment
Metal free
Platform technology for delivering different drugs

Applications

Target drug delivery system for eye or skin diseases

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