Prodrugs for the Treatment of Enteric Inflammatory Diseases (EIDs)

The great quantity of microbes that call the human intestine home have far-reaching influences on human and animal health. Dietary fiber, such as complex polysaccharides, drive gut homeostasis by providing a food source to the intestinal microbiome. Mixed-linkage β(1,3)/β(1,4)-glucan (MLG) is a key plant cell wall polysaccharide with long-recognized health benefits. Its degradation depends on the resident microbiota. Professor Brumer works on unravelling the intricate strategies adopted by the gut symbiont B. ovatus and other Bacteriodetes species to utilize MLG [1, 2]. Together with collaborators in the Canadian Glycomics Network (GlycoNet), Professor Brumer and co-workers have designed and synthesized prodrugs for the treatment of acute and chronic enteric inflammatory diseases in humans and animals. Robyn Law (604) 827-4430

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