Repurposing Drugs (Rice)

In the near term, virologist Charlie Rice, who won the Lasker Award for developing the methods that enabled high throughput screens that led to the cure for hepatitis C, is developing related high-throughput assays to screen for new inhibitors of SARS-CoV-2 replication and also developing coronavirus replicon systems with convenient reporters that can be used for testing novel molecules for their ability to inhibit SARS-CoV-2 replication. He is collaborating with Fraser Glickman, who directs the Rockefeller High Throughput and Spectroscopy resource center, who has assembled a large collection of registered drugs from around the world and others that have been safe in humans but have not been registered for any therapy. Success with any of these would have a rapid route to FDA approval and clinical use. Charles Rice charles.rice@rockefeller.edu 212-327-8000