Structure Based Design of Anti-Parkinson’s Disease Compounds Targeting Synuclein Oligomerization

Researchers at UC San Diego’s School of Medicine have invented a nanostructured device with a significantly improved ZT figure of merit. The pathogenesis of many neurodegenerative diseases (i.e., Parkinson’s disease and Lewy body dementia) is believed to involve the accumulation of alpha-synuclein, although how this buildup results in neuronal degeneration is still unclear. It has been shown that under pathological conditions, alpha-synuclein can aggregate into pentamers and hexamers that form pore-like structures. A better understanding of these oligomerization dynamics and subsequent fibril formation may lead to new avenues of treatment for Parkinson’s disease or other neurodegenerative diseases characterized by this type of aggregation phenomenon. University of California, San Diego Office of Innovation and Commercialization 858.534.5815

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