System for Patterned Illumination Microscopy

Existing structured illumination microscopy can increase the resolution of an image by a factor of 2, however, it requires expensive optical or mechanical devices (e.g., spatial light modulators, digital micromirror devices, or piezo translation stages). Also, the existing movable patterned mask generated by the light interference using SLM or DMD suffers from hysteresis and repeatability problems due to mechanical motion. UC Berkeley researchers have developed a computational illumination hardware and software system that can achieve pattern-shift on the object plane without mechanically switching the patterns and therefore without movement of any component. The lensless system can be easily implemented into existing microscopes without extra hardware can can be extremely fast and suitable for real-time imaging applications. Terri Sale terri.sale@berkeley.edu 510-643-4219