Test Kits to Distinguish Smokers from Non-Smokers – IP 1746

DNA methylation is one of the epigenetic mechanisms for generegulation, and tobacco-smoking can altered this mechanism. Currently availabletechniques to distinguish current smokers from never smokers, based on DNAmethylation status, use chip arrays and require large amounts of DNA andlaborious bioinformatic analysis, making them unsuitable for forensic or otherapplications with limited samples. FIU inventors have developed kits and methods to identifyDNA methylation status at specific gene locations in a cell (CpG sites), whichhelp identify smoking habits of the person from which the cell originated. Thekits comprise specific sets of polymerase chain reaction (PCR) primers designedto amplify the CpG sites of interest, and optionally a sequencing primerdesigned to sequence the amplicon produced by the PCR. Anne Laure Schmitt Olivier aschmitt@fiu.edu 305-348-5948

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