Therapeutic to Treat Infections Caused by Schistosomiasis

According to the CDC, Schistosomiasis, also known as bilharzia, is a disease caused by parasitic worms. Although the worms that cause schistosomiasis are not found in the United States, people are infected worldwide. In terms of impact this disease is second only to malaria as the most devastating parasitic disease. Schistosomiasis is considered one of the neglected tropical diseases (NTDs). The parasites that cause schistosomiasis live in certain types of freshwater snails. The infectious form of the parasite, known as cercariae, emerge from the snail into the water. You can become infected when your skin comes in contact with contaminated freshwater. Most human infections are caused by Schistosoma mansoni, S. haematobium, or S. japonicum. According to WHO, 218 million people required preventive treatment in 2015. Up until 2017, transmission of the diseases has been reported from 78 countries. This clearly showcases the need for effective treatment against all form of Schistosomiasis. Researchers from UTSA, UT Health San Antonio, and Texas Biomedical Research Institute have developed 3,3’ disubstitutedpyrrolidine derivatives as useful thereapeutics to treat infections by Schistosoma mansoni,Schistosoma haematobium and Schistosoma japonicum and to be used incombination therapy with praziquantel. Currently praziquantel is the primary drugused to treat schistosomiasis. Robert Graham robert.graham@utsa.edu (210) 458-8139

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