Thermostable Site-Specific Integrase

Tyrosine recombinases, including integrases, are powerful research tools in genetic manipulation, construction of transgenic organisms and manipulation of cell lines. SiteΓÇÉspecific integrases perform rearrangements of DNA segments by recognizing and binding to short DNA sequences (sites), at which they cleave the DNA backbone, exchange strands between the two DNA helices involved, and rejoin the DNA strands. However, current integrases lack adequate thermal properties ΓÇô they must be cooled on ice and their viability is timeΓÇÉlimited at room temperature. Nick Zelver nzelver@montana.edu 406-994-7706

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