Treatment of Nervous System Injury and Neurodegenerative Disorders and Related Conditions Using a Condroitin Sulfate Proteoglycans Reduction Peptide

Chondroitin sulfate proteoglycan (CSPG) is the major components of scars, which increases significantly after injury/trauma to both peripheral nervous system (PNS) and central nervous system (CNS). Currently, there is no clinically applicable strategy to reduce CSPG. The designed CSPG reduction peptide (CRP) includes an N-terminal cell membrane-penetrating domain, a central CSPG binding domain, and a C-terminal lysosome-targeting domain for directing the CRP-CSPG complex to lysosomes for degradation. CRP is translatable because it is a small peptide and can be easily delivered by subcutaneous injection. By decreasing pathological increases in CSPG, CRP can repair nervous system injury, which in turn leads to functional recovery. Technology has been validated in animal models and compared to published approaches Jason Ospina ospinaj2@ccf.org 216-445-2330

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