UIC-2004-040 – Polyclonal Antibodies Against Elements of the Human Parasites Brugia malayi and S. mansoni

B. malayi, the causative agent for elephantiasis, is a mosquito-borne parasitic filamentary nematode that is endemic in many tropical regions. The larval form of B. malayi migrates to the lymphatic system of human hosts where it matures. The edema caused by the maturation of the parasite results in the swelling and tissue growths associated with elephantiasis. S. mansoni is one of three species of helminth parasite responsible for schistosomiasis, a debilitating liver disease that is endemic to many tropical regions. The function of Sm-GBF in S. mansoni is not presently known. It is anticipated that it will have regulatory functions similar to those of other G-binding proteins. This invention consists of rabbit polyclonal antibodies that are specific: for the Translationally Controlled Tumor Protein (Bm-TCTP) human parasite Brugia malayi (CX040); for abundant Larval Transcript (ALT) protein of human parasite Brugia malayi (CX041); for the G-Binding Factor (GBF) protein of the human parasite S. mansoni (CX042); for anti-inflammatory protein Sm-16 that is produced by the human parasite S. mansoni (CX043); against the cercariae stage of the human parasite S. mansoni (CX044); for the Translationally Controlled Tumor Protein (Sm-TCTP) of the human parasite S. mansoni (CX045); and for the 28kDa Glutathione-S-Transferase (GST) protein of the human parasite S. mansoni (CX046). Hyunjin Kim hkim227@otm.uic.edu 312355-7843