UIC-2007-016 – Identification of 12-MER Novel Peptides that Blocks Herpes Simplex Virus Type-1 Entry into Primary Human Cell Culture Models

Currently there are no vaccines or treatments that prevent Herpers Simplex Virus-1 (HSV-1). The inventor has identified specific peptides to heparan sulfate that could possibly be a prophylactic or therapeutic agent against Herpes infection. The peptide blocks Herpes Simplex Virus –1 from entering cells. HSV-1 is a herpes virus that infects humans and some other animals producing small, transient blisters on the skin or mucous membranes (usually associated with oral herpes). Heparan sulfate has been identified as a therapeutic target for HSV-1. The (12-mer) peptide has been identified specific to heparan sulfate, therefore forming a prophylactic for prevention of HSV-1. Jonathan Gortat jgortat@otm.uic.edu (312) 413-1643