UIC-2009-005 – Unique similarity of Angiotensin II sequence and ability to detect apoptosis in all tissues and species

Angiotensin II induces apoptosis in various cell types. Angiotensin II has been shown to be involved in both extrinsic (directly transducing the signal via adapter proteins to the apoptotic mechanisms) and intrinsic (targeting mitochondria functionality) mechanisms of apoptosis. Hence the technology proposes the use of angiotensin as a marker for apoptosis in all tissue types and in all species. Angiotensin II differs by only one amino acid across species. Hence it can be used as a universal marker for detection of apoptosis across all species, cell and tissue types. Nelson Grihalde grihalde@otm.uic.edu 312-996-4129

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