UIC-2010-081 & 2015-040 – Highly Selective and Safer 5-HT2c Receptor Agonists for the treatment of CNS diseases, Bipolar Disorder, Schizophrenia and Obesity

Dr. Alan Kozikowski , professor at UIC College of Pharmacy, has developed a new series of agonists to the 5-HT2c receptor limiting activity at both 5-HT2a and 5-HT2b receptors. The modifications lead to the discovery of agonists with high selectivity and potency against the 5HT2c receptor. The 5-hydroxytryptamine 2C (5-HT2c) receptor is a subtype of serotonin receptor found throughout the central nervous system involved with several behavioral processes including mood, appetite, and sexual behavior. Compounds have been characterized for PK, hERG binding, Microsomal stability and dosed chronically with excellent tolerance. Nelson Grihalde grihalde@otm.uic.edu 312-996-4129

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