UIC-2012-046 – Mouse monoclonal antibody for human lipid phosphate phosphatase-3 (LPP3)

UIC inventors have developed a mouse monoclonal antibody which recognizes human lipid phosphate phosphohydrolase 3 (LPP3). An antibody against the extracellular domain of LPP3 inhibits cell-cell interactions and angiogenesis in vitro. In addition, LPP3 not only catalyzes the dephosphorylation of the bioactive lipid sphingosine-1-phosphate (S1P) to generate sphingosine but also may regulate embryonic development and angiogenesis via the Wnt pathway. LPP3 also has the ability to potentiate tumour growth by amplifying B-catenin and CYCLIN-D1 activities. Thus, LPP3 is a potential target for inhibiting the growth of glioblastoma (an aggressive type of brain tumour) and other tumours that express high levels of LPP3, and may serve as a link in the acquisition of proliferative, invasive, and metastatic phenotypes. Veronica Haywood vhaywo2@uic.otm.edu 312-996-4865