UIC-2016-051 – TAT peptides for treatment of cardiac arrest

Cardiac Arrest is the leading cause of death in US in people over 40. There are currently no drugs available improving the survival after sudden cardiac arrest (SCA). TAT-PTEN and TAT-PHLPP are two TAT-based cell permeable peptides, designed for the treatment of cardiac arrest. These peptides target the carboxyl terminal PDZ binding motif of PTEN and PHLPPP phosphatases. These two phosphatases are believed to cause major injury and death after sudden cardiac arrest. The designed peptides will become a first-of-kind class of agents for improving cardiac arrest survival when administered intravenously during CPR. They could also improve other ischemia-related diseases such as stroke, myocardial infarction and hemorrhagic shock. Hyunjin Kim hkim227@otm.uic.edu 312355-7843