UIC-2018-102 – Functionally Activated Targeted Exosomes (FATE)

Exosomes are cell-secreted, nano-scale (40-150nm), lipid layered spheroids packed with celltype specific cargo. Exosomes primarily enable cell-cell communication and transfer of proteins/nucleic acids. They have supporting roles in the immune system, inflammation, differentiation, and regeneration. Exosome research is therefore at the forefront of regenerative medicine, immunology, and cancer research. Loading and targeting schemes for engineered exosomes have been proposed, but none combine both aspects using natural loading and targeting systems. Leading researchers in UIC’s College of Dentistry propose engineered exosomes that optimally induce Stem Cell Lineage Determination (SCLD). These exosomes are products of engineered parental stem cells, and are termed Functionally Activated Targeted Exosomes (FATE). FATE feature functional cargo related to the desired effect—e.g. bone morphogens for bone regeneration. And they feature targeting membrane proteins that keep the exosomes in the desired tissue. Hyunjin Kim hkim227@otm.uic.edu 312355-7843