Various PMST1 Mutants and the Synthesis of a Library of Sialyl Lewis X Containing Different Sialic Acid Forms

Researchers at the University of California, Davis have developed a new method of obtaining a library of sialyl Lewis x and other sialosides containing different sialic acid forms. This method utilizes engineered mutants of sialyltransferase PmST1. These novel mutants show lower donor hydrolysis activity and/or sialidase activity without compromising the sialyltransferase activity. Maris Apse 530-754-8718

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