Materials & Chemicals
Microorganisms For Producing Organic Acids
View U.S. Patent No. 8,846,329 in PDF format.
WARF: P120017US04
Inventors: Brian Pfleger, Matthew Begemann
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The Invention
Organic acid-producing microorganisms and methods of using same. The organic acid-producing microorganisms comprise modifications that reduce or ablate AcsA activity or AcsA homolog activity. The modifications increase tolerance of the microorganisms to such organic acids as 3-hydroxypropionic acid, acrylic acid, propionic acid, lactic acid, and others. Further modifications to the microorganisms increase production of such organic acids as 3-hydroxypropionic acid, lactate, and others. Methods of producing such organic acids as 3-hydroxypropionic acid, lactate, and others with the modified microorganisms are provided. Methods of using acsA or homologs thereof as counter-selectable markers are also provided.
Additional Information
For More Information About the Inventors
Brian Pfleger
Tech Fields
Materials & Chemicals : Biochemicals & biomaterials
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